User:BetsyRogers
| en | This user is a native speaker of the English language. |
.jpg?lang=en){kind=small} | This user is a member of the Association of Structurist Wikipedians. |
 | This user participates in WikiProject Science. |
 | This user participates in WikiProject Medicine. |
 | This user is a participant in WikiProject Genetics. |
 | This user is a member of WikiProject Women scientists. |
 | This user participates in WikiProject Biology. |
 | This user is a member of WikiProject Molecular and Cell Biology. |
 | This user is a member of WikiProject Marine Life. |
 | This user is a participant in WikiProject Women. |
 | This user is a participant in WikiProject Women in Red |
 | This user understands the science behind climate change and makes efforts to mitigate the problem. |
 | This user participates in WikiProject Stub sorting. |
| tyop typo | This user is a member of the Wikipedia Typo Team. |
| , | This user supports the use of the Oxford comma. |
| {{Uncat}} | This user is a member of the Uncategorized Task Force. |
 | This user is a member of WikiProject Orphanage. You can help! |
Me
[edit]Expertise:
[edit]Available to assist as subject matter expert for articles pertaining to:
- Science (general), biology, zoology
- Genetics (incl. molecular biology, medical genetics, genetic testing, phamacogenomics).
- Biochemistry (incl. enzymology, protein chemistry, pharmacodynamics)
- DNA, RNA, proteins (interactions, gene regulation, transcription, replication, DNA damage & repair).
- Marine biology, marine ecosystems, environmental policy
- Healthcare policy, regulatory compliance (incl. FDA, HIPAA)
Other interests:
[edit]Able to assist (e.g., article improvements, cleanup, etc.) but not formally a subject matter "expert":
- Languages (incl etymology, linguistics)
- Women's history, international women's rights, indigious/first peoples cultural history
- United States: civil rights, voting rights, election law, campaign finance law, healthcare reform
- Addressing medical/science misinformation (how I started here)
OPEN ACCESS IMAGES:
[edit]Smithsonian Open Access (usage guidelines)
NOAA photo library (images only)
NASA Images (usage guidelines )
Search Tools
[edit]Wikipedia Advanced Search: Special:Search
Stub category index:
- WikiProject_Stub_sorting#tools
- WikiProject_Stub_sorting/List_of_stubs
- WikiProject_Stub_sorting/Stub_types
- Category:Top-level stub categories
Misc, personal use
[edit]To Do
To Do
|
|---|
|
Make to-do list on user page. (Find template for checklist format) Find standalone box/button for shortcuts? e.g.: watchlist, category search, stub category search, reliable sources, Userbox directory Direct* links to action items pages in WikiProjects |
WikiProjects
Links
Templates
Templates
| ||||||||
|---|---|---|---|---|---|---|---|---|
Templates[edit]Wikipedia:WikiProject_Stub_sorting/Stub_types#/ See also/ distinguish: For x see y: More citations needed (article):
Unreferenced medical section
Unreliable medical source (no box) [unreliable medical source?] Disputed
|
Sandboxes
Sandboxes
|
|---|
Sandboxes[edit]Epigenetic clock: Sandbox2 Pharmacology: Sandbox3 https://en.wikipedia.org/wiki/Wikipedia:Sandbox https://en.wikipedia.org/wiki/Wikipedia:About_the_sandbox https://en.wikipedia.org/wiki/Help:My_sandbox |
Editing⤵️
Editing
|
|---|
|
Epigenetic clock outline Epigenetic Clock outline: Lede:[edit](include short sentence on applications: research on aging, longevity, chronic diseases, and certain cancers) Background (scientific background):[edit]Epigenetics and aging:[edit]- concept of epigenetics (example, methylation) - concept of biomarkers of aging (example telomere length, histones, methylation) - motivation for epigenetic clock - existing section
Epigenetic clocks (general concept):[edit]- explain why methylation lends itself well to development of an epigenetic clock - briefly, specific genes typically used for readout on DNAm levels as related to aging (& why) - brief statement of 1st gen, 2nd gen, 3rd gen, & other types of clocks History[edit](edit existing section) - Hx of epigenetics major findings - Discovery of epigenetic changes that correlate with aging and some diseases. - Methylation-based Epigenetic clocks[edit]1st generation - Horvath, Hannum (explain individually) - include: method (incl genes used), applications, computer algorithm used, advantages vs previous options, limitations) 2nd generation - Levine, - method & genes, applications, advantages, algorithm, limitations as above, including compare/contrast to 1st gen. 3rd gen & others - same as above - include clocks using other markers (i.e., not methylation Practical applications(?)[edit]- include limitations of current methods (collectively) - currently only used for research purposes, for studies related to aging & diseases. - examples of applications (in existing section) Future directions:[edit]- beyond methylation clocks (e.g. histones) - potential use as clinical test? (re overall health/risks, or re disease states) and medical interventions - increasing lifespan may be farther away but improving quality of life (e.g. chronic disease) is within reach. Also see: Epigenetics |
Editing
|
|---|
Editing⬇️[edit](Excerpts, drafts) Epigenetic clock[edit]Add "under construction" message box template Article: Epigenetic clock Sandbox: https://en.wikipedia.org/wiki/User:BetsyRogers/sandbox2 Epigenetic clock: - Add section to reflect other epigenetic clocks from other groups - add sections organized by to 1st-gen, 2nd-gen, 3rd-gen, & "other". - Find open-access infographic explaining epigenetic clock, or at least showing CpG methylation w/age. - More secondary sources (reviews) - Cleanup informal language - move/delete biographical text (move to corresponding biographical article? or get consensus to delete) - update with new developments in field - reorganize headings to facilitate future expansion of article (easy to update with new developments). - organize the section just listing research findings
- Horvath’s Clock (2011 or 2013?): 2011:"Epigenetic Predictor of Age" Bocklandt et al. PLoS One. 2011. https://pubmed.ncbi.nlm.nih.gov/21731603/ (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014821) 2013: "DNA methylation age of human tissues and cell types". BMC Genome Biology (Dec 2013). https://genomebiology.biomedcentral.com/articles/10.1186/gb-2013-14-10-r115 - Hannum’s Clock (2013): Hannum et al, "Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates". Molecular Cell (January 2013). https://www.cell.com/molecular-cell/fulltext/S1097-2765(12)00893-3
Nooh Bocklandt (2011), Skin & Blood Clock (Horvath 2018). refs: Belsky 2015?
ref: An epigenetic biomarker of aging for lifespan and healthspan (Levine et al, 2018) https://pubmed.ncbi.nlm.nih.gov/29676998/
Belsky measures the pace of epigenetic aging rather than a static age in DunedinPACE
Causality-enriched clocks: CausAge, AdaptAge, and DamAge Neural network-based models (e.g., DeepMAge, AltumAge) Ancestry cohorts (e.g., iCAS-DNAmAge =Chinese populations)
Reviews (chronological) Epigenetic clock: A promising biomarker and practical tool in aging Ageing Res Rev (2022 Nov) https://pubmed.ncbi.nlm.nih.gov/36206857/ (https://www.sciencedirect.com/science/article/abs/pii/S1568163722001854) The use of DNA methylation clock in aging research" (2020 Nov) https://pmc.ncbi.nlm.nih.gov/articles/PMC7885055/ What Are Epigenetic Clocks and Their Role in Aging Research https://federalhealthgroup.com/posts/what-are-epigenetic-clocks-and-their-role-in-aging-research/ Using Epigenetic Clocks to Characterize Biological Aging in Studies of Children and Childhood Exposures: a Systematic Review https://pmc.ncbi.nlm.nih.gov/articles/PMC10964791/#R53 Epigenetic clocks and programmatic aging Exploring the correlation between DNA methylation and biological age using an interpretable machine learning framework https://www.sciencedirect.com/science/article/pii/S1568163724003647 A systematic review of phenotypic and epigenetic clocks used for aging and mortality quantification in humans https://pmc.ncbi.nlm.nih.gov/articles/PMC11424583/ See Table 1, "Table 1. Descriptive statistics of all included first-generation epigenetic clocks." -- Big table listing several clocks) Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume https://pmc.ncbi.nlm.nih.gov/articles/PMC9213584/ Epigenetic ageing clocks: statistical methods and emerging computational challenges https://www.nature.com/articles/s41576-024-00807-w DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples https://www.fsigenetics.com/article/S1872-4973(18)30238-2/abstract Methylclock - DNA methylation-based clocks https://www.bioconductor.org/packages/release/bioc/html/methylclock.html methylclock software pkg https://isglobal-brge.github.io/methylclock/index.html "methylclock package allows to estimate chronological and gestational DNA methylation (DNAm) age as well as biological age using different methylation clocks. The package includes the following estimators..." (tech specs on a *lot* of clocks) "Universal DNA methylation age across mammalian tissues" Nat Aging, Aug 2023. https://pmc.ncbi.nlm.nih.gov/articles/PMC10501909/ |
Editing
|
|---|
Editing⬇️[edit]Pharmacodynamics[edit]Pharmacodynamics. Cleanup biophysics terms (definitions, methods), add citations.
Pharmacology outline[edit]Title: Pharmacology Overview[edit](Definition, etc) Etymology[edit]History[edit]Origins of Pharmacology ( ___ B.C.)[edit]18th & 19th centuries[edit]Modern Pharmacology[edit]-pharmacology research, general info small paragraph -medical applications, general general info Scientific Principles of Pharmacology[edit]overview[edit]incl background knowledge fields, e.g organic chem, biochem, cell bio, synthetic chem? etc) drug mechanism of action[edit]pharmacodynamics[edit]pharmacokinetics[edit]toxicology[edit]pharmacogenomics[edit]Medical Pharmacology, Therapeutics[edit]overview[edit]applied pharmacology, i.e. relates to pharmacy practice, medical practice, clinical trials drug classification[edit]-chemical class (can apply to multiple organ systems) -organ systems (can include multiple drug classes) -disease types (can impact multiple organ systems and include multiple drug classes) patient safety[edit]-drug toxicity (mechanisms, signs, and risk factors) -drug interactions (drug-drug, drug-food, drug-supplement) -drug dependency Drug Discovery, Drug Development[edit]overview[edit]Drug design[edit]Preclinical research & development[edit]Clinical research, clinical trials[edit]Drug Safety[edit]Drug Efficacy[edit]Regulatory oversight[edit]Emerging fields[edit]-e.g., drugs + gut microbiome External Sources[edit]https://www.britannica.com/science/pharmacology https://www.merckmanuals.com/home/drugs/drug-dynamics/drug-action https://www.bumc.bu.edu/ppb/pharmacology-glossary/ |
Editing
|
|---|
Editing⬇️[edit]Oxygen cocktail[edit]RfD? Oxygen cocktail: clarify this is *not* a medical treatment, address misinformation. Anti-inflammatory[edit]Anti-inflammatory |
- User en-N
- User es-3
- User it-1
- Structurist Wikipedians
- WikiProject Science participants
- Wikipedians interested in science
- WikiProject Medicine participants
- Wikipedians interested in medicine
- WikiProject Genetics participants
- WikiProject Women scientists participants
- WikiProject Biology participants
- Wikipedians interested in biology
- WikiProject Women participants
- WikiProject Women in Red participants
- WikiProject Stub sorting participants
- Wikipedians on the Typo Team
- Wikipedians working on uncategorized articles
- Stub categories
- Wikipedians who edit by smartphone