Toremifen

Toremifen
Klinički podaci
Prodajno ime	Acapodene, Farestone, Toremifene Base, Toremifeno [Spanish]
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	5 dana
Identifikatori
CAS broj	89778-26-7
ATC kod	L02BA02 (WHO)
PubChem	CID 3005573
DrugBank	DB00539
ChemSpider	2275722
KEGG	C08166
ChEBI	CHEBI:9635
ChEMBL	CHEMBL1655
Hemijski podaci
Formula	C26H28ClNO
Molarna masa	405,960
	SMILES CN(C)CCOC1=CC=C(C=C1)C(=C(\CCCl)C1=CC=CC=C1)\C1=CC=CC=C1; ;
	InChI InChI=1S/C26H28ClNO/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21/h3-16H,17-20H2,1-2H3/b26-25- ; Key:XFCLJVABOIYOMF-QPLCGJKRSA-N ;
Fizički podaci
Tačka topljenja	108—110 °C (226—230 °F)

Toremifen je organsko jedinjenje, koje sadrži 26 atoma ugljenika i ima molekulsku masu od 405,960 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	0
Broj rotacionih veza	9
Particioni koeficijent^[8] (ALogP)	6,3
Rastvorljivost^[9] (logS, log(mol/L))	-8,2
Polarna površina^[10] (PSA, Å²)	12,5

Reference

^ Price N, Sartor O, Hutson T, Mariani S (2005 Mar). „Role of 5a-reductase inhibitors and selective estrogen receptor modulators as potential chemopreventive agents for prostate cancer”. Clin Prostate Cancer. 3 (4): 211—4. PMID 15882476. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Taneja SS, Smith MR, Dalton JT, Raghow S, Barnette G, Steiner M, Veverka KA (2006 Mar). „Toremifene--a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy”. Expert Opin Investig Drugs. 15 (3): 293—305. PMID 16503765. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Thompson IM: Chemoprevention of prostate cancer: agents and study designs. J Urol. 2007 Sep;178(3 Pt 2):S9-S13. Epub 2007 Jul 20. . PMID 17644117. Недостаје или је празан параметар |title= (помоћ)
^ Ariazi EA, Ariazi JL, Cordera F, Jordan VC (2006). „Estrogen receptors as therapeutic targets in breast cancer”. Curr Top Med Chem. 6 (3): 181—202. PMID 16515478.
^ Musa MA, Khan MO, Cooperwood JS (2007). „Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs)”. Curr Med Chem. 14 (11): 1249—61. PMID 17504144.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Toremifene

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Price N, Sartor O, Hutson T, Mariani S (2005 Mar). „Role of 5a-reductase inhibitors and selective estrogen receptor modulators as potential chemopreventive agents for prostate cancer”. Clin Prostate Cancer. 3 (4): 211—4. PMID 15882476. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[2] Taneja SS, Smith MR, Dalton JT, Raghow S, Barnette G, Steiner M, Veverka KA (2006 Mar). „Toremifene--a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy”. Expert Opin Investig Drugs. 15 (3): 293—305. PMID 16503765. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[3] Thompson IM: Chemoprevention of prostate cancer: agents and study designs. J Urol. 2007 Sep;178(3 Pt 2):S9-S13. Epub 2007 Jul 20. . PMID 17644117. Недостаје или је празан параметар |title= (помоћ)

[4] Ariazi EA, Ariazi JL, Cordera F, Jordan VC (2006). „Estrogen receptors as therapeutic targets in breast cancer”. Curr Top Med Chem. 6 (3): 181—202. PMID 16515478.

[5] Musa MA, Khan MO, Cooperwood JS (2007). „Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs)”. Curr Med Chem. 14 (11): 1249—61. PMID 17504144.

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[9] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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