Talk:Sublingual administration

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Sublingual ftw

Hard to believe a clump of medication sitting under the tongue really will be completely absorbed. Have proper scientific pharmacokinetic tests ever been done? Can we believe them? — Preceding unsigned comment added by 2601:647:4480:1A90:ED60:4584:BF93:F00B (talk) 04:55, 28 June 2024 (UTC)[reply]

No need for a scientific test. I use it five minutes later. 5.214.235.111 (talk) 17:49, 6 May 2025 (UTC)[reply]

Salvinorin A

It says: "Due to the degradative qualities of the stomach and intestine, or the solubility of the GI tract, certain substances, such as salvinorin A may only be administered orally via the sublingual route." I think this needs to be reworded, because salvinorin A can also be absorbed by smoking. I understand what it's trying to say, but it might be misleading to people who know nothing about salvinorin A. --BennyD 06:37, 30 January 2007 (UTC)[reply]

I fixed it up a little bit. To me it's more clear now. Feel free to change it again if you don't like how I worded it. --BennyD 14:53, 24 October 2007 (UTC)[reply]

I consider salvinorin A to be a very poor example of sublingual drugs, and what "the solubility of the GI tract" means is beyond me. Unfree (talk) 18:56, 31 May 2008 (UTC)[reply]

Why all the talk about Salvinorin A, anyway? It is a rather newly discovered chemical and thus not commonly known, yet it is used as a primary example twice in the article. Did someone have Salvia on their mind while thinking about sublingual administration? --Moeburn (talk) 01:27, 20 October 2008 (UTC)[reply]

A recently published article shows that doses of salvinorin A up to 4 mg administered sublingually has little to no effect. I'm updating the page now with a direct link to the article, but considering it doesn't show Salvinorin A has no effect when administered this way at any dosage, and considering traditionally users of Salvinorin A take the drug sublingually, (in balls of salvia leaves known as a quib ball), I'm not removing references to it's usage. Twin seas (talk) 09:30, 26 January 2012 (UTC)[reply]

Sublingual administration of drugs not intended for it

"Many people are forced by the high cost of pharmaceuticals to split their pills and take them sublingually." This seems to suggest that drugs designed to be administered per os might also be effective when taken sublingually, which is often untrue. Unfree (talk) 18:56, 31 May 2008 (UTC)[reply]

this comment is almost touching on another aspect that may be interesting to add to the articule. Whether some things not thought as being taken into the bloodstream getting there undesirably, not only other medicines, buy things like mouth-washer elements or even toothpaste elements, or maybe even some food stuff which for some reason wouldn't be desirable to take this route. — Preceding unsigned comment added by 200.150.252.98 (talk) 17:02, 19 October 2025 (UTC)[reply]

More examples would be helpful

What drugs are commonly taken sublingually, what molecular weight is too big for sublingual administration? These are the sorts of questions that the article does not answer, which seem like the first questions that would come to mind that would lead someone to read the article. — Preceding unsigned comment added by 74.65.210.106 (talk) 04:21, 31 May 2015 (UTC)[reply]

Snus

Would the route of administration of Snus technically be "sublingual"? 4.255.50.66 (talk) 18:01, 28 September 2009 (UTC)[reply]

NPOV?

What about the disadvantages of sublinguals? Surely there are at least some. Only one view is represented and this article is obviously biased. —Preceding unsigned comment added by 96.51.11.91 (talk) 00:10, 29 December 2009 (UTC)[reply]

Merge proposal

We have a set of articles covering subtle variants of oral mucosal absorption. Given the overlap in the topics, I suggest merging Sublingual administration, Supralingual administration and Sublabial administration into a new article on Oral mucosal absorption. The reasons for this are short text, context and overlap. I'd also link to Buccal administration, but think that this is large enough to work as a stand-alone article. Klbrain (talk) 10:03, 6 September 2025 (UTC)[reply]

Oppose this proposal – This article is large enough to stand alone. The title "Oral mucosal absorption" does not suggest that it is a ROA. I would support merging Supralingual administration and Sublabial administration into Route of administration. If it is alright with you, I could merge those articles right now. Slothwizard (talk) 20:42, 17 September 2025 (UTC)[reply]

I boldly merged Supralingual administration and Sublabial administration into Route of administration. Let me know if anything. Slothwizard (talk) 20:06, 27 September 2025 (UTC)[reply]