Modified Maddrey's discriminant function
ModifiedGolle diisnondiral Maddrey (DF) ko mbaadi aadaaji ngam ƴeewde tiiɗnaare e ƴeewndo e nder hepatitis alkol e ƴeewtaade nafoore huutoraade safaara steroid hepatitis alkol. Njoɓdi Maddrey DF ko mbaydi limto teskaandi, ina renndina njoɓdi DF neɗɗo oo e ƴeewndo maayde e nder balɗe 30 walla 90.[laɓɓitingol ina haani] Njoɓdi Maddrey DF neɗɗo oo ina anndiree e ƴeewndo ƴiiƴam.[1]
Golle diisnondiral Maddrey baylaaɗe ɗee, ko Maddrey e Boitnott cifondiri ɗum e fuɗɗoode ngam teskaade ko waawi arde e hepatitis alkol. Ina hiisee e foormula koolaaɗo kuutortooɗo waktu protrombin e njuuteendi bilirubin e nder ƴiiƴam:[citation needed].[2].[3][4]
(
4.6
×
(
sahaa porotrombin
−
waktu ɗowgol
)
)
+
bilirubin e nder ƴiiƴam e nder mg/dl
{\displaystyle \nano(4.6\laabi \nano({\hbox{waktu porotrombin}}-{\hbox{waktu ƴeewndo}}\nyaamo)\nyaamo)+{\hbox{bilirubin ƴiiƴam e nder mg/dl}}}
Wiɗtooji garooji kollitii wonde ina waɗi nafoore e teskaade ñawu nguu e nder balɗe 30, haa teeŋti noon e maayde e nder balɗe 30. Nafoore ɓurnde 32 ina hollita batte bonɗe e maayde lewru wooturu ina wona hakkunde 35% e 45%. Kortikosteroid walla pentoksifiliin huutoraama e batte jillondirɗe wonande ñawɓe ɓe ɓeydagol maayde mum en hollirtee e nafoore ɓurnde 32.
Ngam hiisaade golle diisnondiral Maddrey kuutortooɗe yuɓɓooji SI, ko wayi no mikroomol e liiteer gooto, feccu teddeendi bilirubin e 17.
Ƴeew kadi
[taƴto | taƴto ɗaɗi wiki]Model ngam ñawu heege joofnirde
Cukalel-Pugh limre
Doggol
Tuugnorgal[5]
[taƴto | taƴto ɗaɗi wiki]- ↑ Carithers RL, Jr; Herlong, HF; Diehl, AM; Shaw, EW; Combes, B; Fallon, HJ; Maddrey, WC (1 May 1989). "Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial". Annals of Internal Medicine. 110 (9): 685–90. doi:10.7326/0003-4819-110-9-685. PMID 2648927.
- ↑ Sheth M, Riggs M, Patel T (2002). "Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis". BMC Gastroenterology. 2. doi:10.1186/1471-230X-2-2. PMC 65516. PMID 11835693. Unknown parameter
|article-number=ignored (help) - ↑ Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O (2000). "Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial". Gastroenterology. 119 (6): 1637–48. doi:10.1053/gast.2000.20189. PMID 11113085. S2CID 6601371.
- ↑ Mathurin P, O'Grady J, Carithers RL, Phillips M, Louvet A, Mendenhall CL, Ramond MJ, Naveau S, Maddrey WC, Morgan TR (2011). "Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data". Gut. 60 (2): 255–60. doi:10.1136/gut.2010.224097. PMID 20940288. S2CID 421366.
- ↑ Maddrey WC, Boitnott JK, Bedine MS, Weber FL, Mezey E, White RI (1978). "Corticosteroid therapy of alcoholic hepatitis". Gastroenterology. 75 (2): 193–9. doi:10.1016/0016-5085(78)90401-8. PMID 352788.