LEFTY1

LEFTY1
Identifikatori
Aliasi	LEFTY1
Vanjski ID-jevi	OMIM: 603037 MGI: 107405 HomoloGene: 49231 GeneCards: LEFTY1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	225,911,382 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	180,765,965 bp
Ontologija gena
Molekularna funkcija	• transforming growth factor beta receptor binding; • cytokine activity; • growth factor activity;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• regulation of apoptotic process; • multicellular organism development; • positive regulation of pathway-restricted SMAD protein phosphorylation; • heart morphogenesis; • determination of left/right symmetry; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transforming growth factor beta receptor signaling pathway; • regulation of MAPK cascade; • SMAD protein signal transduction; • cell development; • BMP signaling pathway; • regulation of signaling receptor activity;
	Izvori:Amigo / QuickGO
Ortolozi
	10637
	13590
	ENSG00000243709
	ENSMUSG00000038793
	O75610
	Q64280
	NM_020997
	NM_010094
	NP_066277
	NP_034224
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Faktor 1 određenja lijevo-desno jest protein koji je kod ljudi kodiran genom LEFTY1 sa hromosoma 1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 366 aminokiselina, a molekulska težina Da. 40.880 ^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MQPLWLCWAL	WVLPLASPGA	ALTGEQLLGS	LLRQLQLKEV	PTLDRADMEE
LVIPTHVRAQ	YVALLQRSHG	DRSRGKRFSQ	SFREVAGRFL	ALEASTHLLV
FGMEQRLPPN	SELVQAVLRL	FQEPVPKAAL	HRHGRLSPRS	ARARVTVEWL
RVRDDGSNRT	SLIDSRLVSV	HESGWKAFDV	TEAVNFWQQL	SRPRQPLLLQ
VSVQREHLGP	LASGAHKLVR	FASQGAPAGL	GEPQLELHTL	DLGDYGAQGD
CDPEAPMTEG	TRCCRQEMYI	DLQGMKWAEN	WVLEPPGFLA	YECVGTCRQP
PEALAFKWPF	LGPRQCIASE	TDSLPMIVSI	KEGGRTRPQV	VSLPNMRVQK
CSCASDGALV	PRRLQP

Funkcija

Ovaj gen kodira člana porodice proteina TGF-beta. Sličan izlučeni protein kod miša ima ulogu u određivanju asimetrije lijevo-desno u sistemima organa tokom razvoja. Alternativna prerada ovog proteina može dati tri različita izoformna proizvoda. Ovaj gen je usko povezan i sa srodnim članom porodice i sa srodnim pseudogenom.

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000243709 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038793 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Left-right determination factor 1". Pristupljeno 3. 8. 2016.
↑ "UniProt, O75610" (jezik: engleski). Pristupljeno 13. 12. 2021.

Dopunska literatura

Besser D (2004). "Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3". J. Biol. Chem. 279 (43): 45076–84. doi:10.1074/jbc.M404979200. PMID 15308665.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000243709 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038793 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Left-right determination factor 1". Pristupljeno 3. 8. 2016.

[UniProt-6] "UniProt, O75610" (jezik: engleski). Pristupljeno 13. 12. 2021.

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