Imidazole
Imidazole (ImH) is an organic compound. It is an aromatic ring with five atoms, three carbon and two nitrogen. Its chemical formula is C3H4N2[1] or C3H3(NH)N. Imidazole is an aromatic compound.[2] It is a white or colourless solid at 25 degrees Celsius at standard atmosphere (a pressure). It i is soluble in water, producing a mildly alkaline solution.[source?]
Role in biology
[change | change source]Many natural products, especially alkaloids, have the imidazole ring. This ring system is present in important biological building blocks, such as histidine, and the related hormone, histamine.[source?]
Properties
[change | change source]Only one of the nitrogen atoms in imidizole acts as a base.[3] The other nitrogen atom is bonded to a hydrogen atom that acts like a weak acid.[4] Because it can be both an acid and a base, imidazole is amphoteric.
References
[change | change source]- ↑ "Imidazole". Merriam-Webster Dictionary. Retrieved 2025-09-19.
- ↑ John McMurray (2023-09-20). "15.5 Aromatic Heterocycles: Pyridine and Pyrrole". Organic Chemistry: A Tenth Edition. Houston, TX: OpenStax.
- ↑ John McMurray (2023-09-20). "24.9 Heterocyclic Amines". Organic Chemistry: A Tenth Edition. Houston, TX: OpenStax.
- ↑ Mó, Otilia; Yáñez, Manuel; Alkorta, Ibon; Elguero, José (2013). "Enhancing and modulating the intrinsic acidity of imidazole and pyrazole through beryllium bonds". Journal of Molecular Modeling. 19 (10): 4139–4145. doi:10.1007/s00894-012-1682-y. PMID 23292320.