HLA-C

HLA-C
已知的結構
PDB	人类UniProt搜索: PDBe RCSB
PDBID列表
	3BZF,%%s4NT6,%%s1EFX,%%s1IM9、1QQD
識別號
别名	HLA-C；, D6S204, HLA-JY3, HLC-C, PSORS1, major histocompatibility complex, class I, C, MHC
外部ID	OMIM：142840 HomoloGene：133080 GeneCards：HLA-C
相關疾病
	慢性阻塞性肺病、乾癬性關節炎
基因位置（人类）
染色体	6號染色體
终止	31,272,130 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• peptide antigen binding; • 血浆蛋白结合;
細胞組分	• integral component of membrane; • phagocytic vesicle membrane; • 高尔基体; • early endosome membrane; • 膜; • Golgi membrane; • 细胞膜; • cell surface; • 内质网; • MHC class I protein complex; • ER to Golgi transport vesicle membrane; • integral component of lumenal side of endoplasmic reticulum membrane; • 外排體; • secretory granule membrane; • recycling endosome membrane;
生物學過程	• antigen processing and presentation; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • immune system process; • interferon-gamma-mediated signaling pathway; • antigen processing and presentation of peptide antigen via MHC class I; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; • type I interferon signaling pathway; • 免疫反应; • regulation of immune response; • viral process; • neutrophil degranulation;
	Sources:Amigo / QuickGO
直系同源
	3107
	无数据
ENSG00000204525; ENSG00000233841; ENSG00000228299; ENSG00000225691; ENSG00000206435;
	ENSG00000237022; ENSG00000206452
	无数据
	P10321
	无数据
	NM_002117; NM_001243042
	无数据
	NP_001229971; NP_002108
	无数据
	維基數據
檢視/編輯人類

HLA-C是人類白細胞抗原（HLA）的一个基因座，位于6号染色体上。成熟的HLA-C蛋白会与β2微球蛋白组成异二聚体，作为一个受体锚定在细胞表面。

参考文献

^ 與HLA-C相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000204525、ENSG00000233841、ENSG00000228299、ENSG00000225691、ENSG00000206435、ENSG00000237022、ENSG00000206452 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

延伸阅读

Geyer M, Fackler OT, Peterlin BM. Structure--function relationships in HIV-1 Nef.. EMBO Rep. 2001, 2 (7): 580–5. PMC 1083955 . PMID 11463741. doi:10.1093/embo-reports/kve141.
Greenway AL, Holloway G, McPhee DA; et al. HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.. J. Biosci. 2004, 28 (3): 323–35. PMID 12734410. doi:10.1007/BF02970151.
Bénichou S, Benmerah A. [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]. Med Sci (Paris). 2003, 19 (1): 100–6. PMID 12836198. doi:10.1051/medsci/2003191100.
Leavitt SA, SchOn A, Klein JC; et al. Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.. Curr. Protein Pept. Sci. 2004, 5 (1): 1–8. PMID 14965316. doi:10.2174/1389203043486955.
Tolstrup M, Ostergaard L, Laursen AL; et al. HIV/SIV escape from immune surveillance: focus on Nef.. Curr. HIV Res. 2004, 2 (2): 141–51. PMID 15078178. doi:10.2174/1570162043484924.
Joseph AM, Kumar M, Mitra D. Nef: "necessary and enforcing factor" in HIV infection.. Curr. HIV Res. 2005, 3 (1): 87–94. PMID 15638726. doi:10.2174/1570162052773013.
Anderson JL, Hope TJ. HIV accessory proteins and surviving the host cell.. Current HIV/AIDS reports. 2005, 1 (1): 47–53. PMID 16091223. doi:10.1007/s11904-004-0007-x.

外部链接

Molecular Anthropology Yahoo Group（页面存档备份，存于互联网档案馆）
HLA Allele and Haplotype Frequency Database（页面存档备份，存于互联网档案馆）

[1] 與HLA-C相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000204525、ENSG00000233841、ENSG00000228299、ENSG00000225691、ENSG00000206435、ENSG00000237022、ENSG00000206452 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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