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Protein-coding gene in the species Homo sapiens
Exocyst complex component 3 is a protein that in humans is encoded by the EXOC3 gene .[ 5] [ 6]
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.[ 6]
EXOC3 has been shown to interact with DLG3 [ 7] EXOC4 .[ 7] [ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000180104 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034152 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem . 236 (1): 107– 13. doi :10.1006/abio.1996.0138 . PMID 8619474 . ^ a b "Entrez Gene: EXOC3 exocyst complex component 3" .^ a b Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ (Jun 2003). "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex". Nat. Cell Biol . 5 (6): 520– 30. doi :10.1038/ncb990 . PMID 12738960 . S2CID 13444388 . ^ Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (Apr 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin". Nature 422 (6932): 629– 33. Bibcode :2003Natur.422..629I . doi :10.1038/nature01533 . hdl :2027.42/62982 PMID 12687004 . S2CID 4395760 .
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