Clostridium autoethanogenum
| Clostridium autoethanogenum | |
|---|---|
Scientific classification 
| |
| Domain: | Bacteria |
| Kingdom: | Bacillati |
| Phylum: | Bacillota |
| Class: | Clostridia |
| Order: | Eubacteriales |
| Family: | Clostridiaceae |
| Genus: | Clostridium |
| Species: | C. autoethanogenum
|
| Binomial name | |
| Clostridium autoethanogenum Abrini et al. 1994
| |
Clostridium autoethanogenum is an anaerobic bacterium that produces ethanol from carbon monoxide, in so-called syngas fermentation, being one of the few known microorganisms to do so. It is gram-positive, spore-forming, rod-like, motile, and was first isolated from rabbit feces. Its type strain is strain JA1-1.[1] Its genome has been sequenced,[2] and the genes required for utilizing carbon monoxide as a sole carbon and energy source have been determined.[3]
As a chemoautotrophic gas-fermenting organism, it possesses the Wood-Ljungdahl carbon fixation pathway, which allows the conversion of C1-gases into the biomass precursor acetyl-CoA and other specific products, while generating ATP for growth.[4]
Uses
[edit]This species is the key to the technology developed by Lanzatech to produce ethanol on a commercial scale from waste carbon monoxide gas of factory emissions.[5] On a laboratory scale, reports include production of butanol, 3-hydroxybutyrate, ethylene glycol and other compounds.[4]
References
[edit]- ^ Bruno-Barcena, J. M.; Chinn, M. S.; Grunden, A. M. (2013). "Genome Sequence of the Autotrophic Acetogen Clostridium autoethanogenum JA1-1 Strain DSM 10061, a Producer of Ethanol from Carbon Monoxide". Genome Announcements. 1 (4): e00628-13–e00628-13. doi:10.1128/genomeA.00628-13. ISSN 2169-8287. PMC 3744686. PMID 23950130.
- ^ Woods, Craig; Humphreys, Christopher M.; Tomi-Andrino, Claudio; Henstra, Anne M.; Köpke, Michael; Simpson, Sean D.; Winzer, Klaus; Minton, Nigel P. (2022-04-12). Nojiri, Hideaki (ed.). "Required Gene Set for Autotrophic Growth of Clostridium autoethanogenum". Applied and Environmental Microbiology. 88 (7): e02479–21. Bibcode:2022ApEnM..88E2479W. doi:10.1128/aem.02479-21. ISSN 0099-2240. PMC 9004356. PMID 35285680.
- ^ a b Wan, Sai; Lai, Mingchi; Gao, Xinyu; Zhou, Mingxin; Yang, Song; Li, Qiang; Li, Fuli; Xia, Lin; Tan, Yang (2024-03-01). "Recent progress in engineering Clostridium autoethanogenum to synthesize the biochemicals and biocommodities". Synthetic and Systems Biotechnology. 9 (1): 19–25. doi:10.1016/j.synbio.2023.12.001. ISSN 2405-805X. PMC 10776380. PMID 38205027.
- ^ Heffernan, James K.; Valgepea, Kaspar; de Souza Pinto Lemgruber, Renato; Casini, Isabella; Plan, Manuel; Tappel, Ryan; Simpson, Sean D.; Köpke, Michael; Nielsen, Lars K.; Marcellin, Esteban (2020-03-27). "Enhancing CO2-Valorization Using Clostridium autoethanogenum for Sustainable Fuel and Chemicals Production". Frontiers in Bioengineering and Biotechnology. 8 204. doi:10.3389/fbioe.2020.00204. ISSN 2296-4185. PMC 7135887. PMID 32292775.
Further reading
[edit]- Guo, Ying; Xu, Jingliang; Zhang, Yu; Xu, Huijuan; Yuan, Zhenhong; Li, Dong (2010). "Medium optimization for ethanol production with Clostridium autoethanogenum with carbon monoxide as sole carbon source". Bioresource Technology. 101 (22): 8784–8789. Bibcode:2010BiTec.101.8784G. doi:10.1016/j.biortech.2010.06.072. ISSN 0960-8524. PMID 20619639. *Cotter, Jacqueline L.; Chinn, Mari S.; Grunden, Amy M. (2008). "Ethanol and acetate production by Clostridium ljungdahlii and Clostridium autoethanogenum using resting cells". Bioprocess and Biosystems Engineering. 32 (3): 369–380. doi:10.1007/s00449-008-0256-y. ISSN 1615-7591. PMID 18726618. S2CID 3041917.
- Liew, Fungmin Eric; Nogle, Robert (2022). "Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale". Nature Biotechnology. 40 (3): 335–344. doi:10.1038/s41587-021-01195-w. OSTI 1846527. PMID 35190685.
External links
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