Benzomorphan
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| Names | |
|---|---|
| IUPAC name
6,7-Benzomorphan
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Other names
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C12H15N | |
| Molar mass | 173.259 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Benzomorphan is a chemical compound that is the base for a series of drugs which variably act on the sigma receptors and κ-opioid receptors, including the following compounds:
- 5,9-DEHB
- 8-CAC
- Alazocine
- Anazocine
- Bremazocine
- Butinazocine
- Carbazocine
- Cogazocine
- Cyclazocine
- Dezocine
- Eptazocine (Homobenzomorphan)
- Etazocine
- Ethylketocyclazocine
- Fluorophen
- Gemazocine
- Gpa-1657 [14578-59-7][1]
- GPA 1658 HCl salt: [26862-29-3][2]
- GPA-208
- GPA-3154 Fb: [35758-34-0] HCl salt: [35758-32-8]
- Ibazocine
- ID-1229 [56390-16-0][3][4][5]
- LP-1[6]
- Ketazocine
- Metazocine
- Moxazocine
- Mr2266 [56649-76-4]
- MR-2034, MR-2033-CL [57236-85-8]
- Pentazocine
- Phenazocine
- Quadazocine
- Thiazocine[citation needed]
- Tonazocine
- Volazocine
- Zenazocine
Some of these agents are used as analgesics, including pentazocine, phenazocine, dezocine, and eptazocine.[7][8]
See also
[edit]References
[edit]- ^ Yokoyama N, Almaula PI, Block FB, Granat FR, Gottfried N, Hill RT, McMahon EH, Munch WF, Rachlin H, Saelens JK, Siegel MG, Tomaselli HC, Clarke FH. Syntheses, analgetic activity, and physical dependence capacity of 5-phenyl-6,7-benzomorphan derivatives. J Med Chem. 1979 May;22(5):537-53. doi: 10.1021/jm00191a016. PMID: 37335.
- ^ Yokoyama, N., Block, F. B., Clarke, F. H. (May 1970). "1,2,3,4,5,6-Hexahydro-6-phenyl-2,6-methano-3-benzazocines. II". Journal of Medicinal Chemistry. 13 (3): 488–492. doi:10.1021/jm00297a034.
- ^ Castañer, J., Paton, D. M. (1978). "ID-1229". Drugs of the Future. 3 (4): 298. doi:10.1358/dof.1978.003.04.65215. ISSN 0377-8282. Retrieved 21 October 2025.
- ^ Yamamoto H, Saito C, Inaba S, Inukai T, Kobayashi K (May 1975). "The synthesis and pharmacology of a new analgesic, ID-1229". Arzneimittel-Forschung. 25 (5): 795–801. doi:10.1002/chin.197534266. PMID 1242327.
- ^ Yamamoto, H., Saito, C., Inaba, S., Inukai, T., Kobayashi, K., Fukumaru, T., Koga, Y., Homma, T., Asami, Y. (26 August 1975). "ChemInform Abstract: THE SYNTHESIS AND PHARMACOLOGY OF A NEW ANALGESIC, ID‐1229". Chemischer Informationsdienst. 6 (34) chin.197534266. doi:10.1002/chin.197534266. ISSN 2199-2924 0009-2975, 2199-2924. Retrieved 21 October 2025.
{{cite journal}}: Check|issn=value (help) - ^ Parenti C, Turnaturi R, Aricò G, Marrazzo A, Prezzavento O, Ronsisvalle S, Scoto GM, Ronsisvalle G, Pasquinucci L. Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. Life Sci. 2012 Jun 27;90(25-26):957-61. doi: 10.1016/j.lfs.2012.04.041. Epub 2012 May 11. PMID: 22580287.
- ^ Kar, Ashutosh (2005). Medicinal Chemistry - Google Books. ISBN 978-81-224-1565-0.
- ^ Cittern PA, Kapoor VK, Parfitt RT (October 1986). "Preparation and analgesic activity of (−)-11 alpha-substituted 1,2,3,4,5,6-hexahydro-6 alpha,7-(methyleneoxy)-2,6-methano-3-benzazocines". Journal of Medicinal Chemistry. 29 (10): 1929–33. doi:10.1021/jm00160a022. PMID 2876100.
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