2-APQC
Appearance
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| Drug class | Sirtuin-3 (SIRT3) activator |
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| Chemical and physical data | |
| Formula | C23H24FN5O |
| Molar mass | 405.477 g·mol−1 |
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2-APQC is a drug which acts as a sirtuin-3 (SIRT3) activator. In animal studies, it improved muscle and heart function in aged mice.[1][2]
References
[edit]- ^ Peng F, Liao M, Jin W, Liu W, Li Z, Fan Z, et al. (May 2024). "2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis". Signal Transduction and Targeted Therapy. 9 (1) 133. doi:10.1038/s41392-024-01816-1. PMC 11094072. PMID 38744811.
- ^ Xu C, Xiong L, Chen J, Liu Q, Wang F, Fu X, et al. (2025). "Sirtuin 3 modulation by high phosphates: a potential mechanism in muscle aging and sarcopenia". American Journal of Translational Research. 17 (6): 4187–4197. doi:10.62347/JWEY8421. PMC 12261155. PMID 40672597.