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1F-LSD

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Not to be confused with 1-Formyl-LSD.
1F-LSD
Clinical data
Other names1-(Furan-2-carbonyl)-LSD; 1-(2-Furoyl)-LSD; SYN-L-005; N,N-Diethyl-1-(furan-2-carbonyl)-6-methyl-9,10-didehydroergoline-8β-carboxamide
Routes of
administration		Oral
Drug classSerotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
  • (6aR,9R)-N,N-diethyl-4-(furan-2-carbonyl)-7-methyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
PubChem CID
Chemical and physical data
FormulaC25H27N3O3
Molar mass417.509 g·mol−1
3D model (JSmol)
  • CCN(CC)C(=O)[C@H]1CN([C@@H]2CC3=CN(C4=CC=CC(=C34)C2=C1)C(=O)C5=CC=CO5)C
  • InChI=1S/C25H27N3O3/c1-4-27(5-2)24(29)17-12-19-18-8-6-9-20-23(18)16(13-21(19)26(3)14-17)15-28(20)25(30)22-10-7-11-31-22/h6-12,15,17,21H,4-5,13-14H2,1-3H3/t17-,21-/m1/s1
  • Key:VHDXVHVDSPZVCI-DYESRHJHSA-N

1F-LSD, also known as 1-(furan-2-carbonyl)-LSD, 1-(2-furoyl)-LSD, or SYN-L-005, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2] It is thought to act as a prodrug of LSD.[1][2] The drug interacts with serotonin receptors, including the serotonin 5-HT2A receptor, and produces the head-twitch response in rodents, with about 3-fold lower potency than LSD.[1] It hydrolyzes into LSD in rodents.[1] 1F-LSD was patented in 2024[2] and was first described in the scientific literature in 2025.[1] It has been encountered as a novel designer drug in Germany and Japan.[1]

Interactions

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See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

See also

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References

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  1. ^ a b c d e f Brandt SD, Kavanagh PV, Gare S, Elliott SP, Stratford A, Halberstadt AL (August 2025). "Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD)". Drug Test Anal. 17 (8): 1283–1293. doi:10.1002/dta.3829. PMC 12319525. PMID 39624022.
  2. ^ a b c WO 2024/028495, Stratford A, Williamson JP, "Prodrugs of Substituted Ergolines", published 8 February 2024, assigned to Synex Holdings BV 
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