Arxiozyma heterogenica
| Arxiozyma heterogenica | |
|---|---|
Scientific classification 
| |
| Kingdom: | Fungi |
| Division: | Ascomycota |
| Class: | Saccharomycetes |
| Order: | Saccharomycetales |
| Family: | Saccharomycetaceae |
| Genus: | Arxiozyma |
| Species: | A. heterogenica
|
| Binomial name | |
| Arxiozyma heterogenica (Kurtzman & Robnett) Q.M. Wang, Yurkov & Boekhout 2024[1]
| |
| Subspecies | |
| Synonyms | |
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Arxiozyma heterogenica is a species of yeast from the family Saccharomycetaceae. In 2024, a commensal strain dubbed K. heterogenica var. weizmannii, isolated from mouse feces, was reported to potentially prevent opportunistic infections by Candida albicans[3], a main causing agent of candidiasis in humans.[4]
Taxonomy
[edit]Arxiozyma heterogenica was first described as 2005 as Kazachstania heterogenica and was found to be closely related to the species in the Kazachstania telluris Complex, which was formed from several former Candida species.[5] Alongside the species in the K. telluris Complex, A. heterogenica was moved to the newly established genus Arxiozyma in 2024.[6]
Ecology
[edit]In contrast to other species in the former K. telluris Complex, commensal strains of A. heterogenica have been reported from rodents.[2]. The presence of one commensal strain in the intestine of mice, originally described as K. heterogenica var. weizmannii, was shown to prevent the colonization by Candida albicans,[3] with several press reports commenting on its potential to combat infections by C. albicans ascribing these findings to a novel species named Kazachstania weizmannii.[7][8]
References
[edit]- ^ a b "Arxiozyma heterogenica". Species synonymy. Species Fungorum. CAB International. Retrieved 13 October 2025.
- ^ a b Kralova JS, Fidel L, Donic C, Ben-Dor S, Jung S (19 March 2024). "Draft genome of Kazachstania heterogenica var. weizmannii, a commensal fungus of the mouse digestive tract". Mycology Resource Announcements. 13 (4) e00115-24. doi:10.1128/mra.00115-24. PMC 11008192. PMID 38501775.
- ^ a b c Kralova JS, Donic C, Dassa B, Livyatan I, Jansen PM, Ben-Dor S, Fidel L, Trzebanski S, Narunsky-Haziza L, Asraf O, Brenner O, Dafni H, Jona G, Boura-Halfon S, Stettner N, Segal E, Brunke S, Pilpel Y, Straussman R, Zeevi D, Bacher P, Hube B, Shlezinger N, Jung S (May 2024). "Competitive fungal commensalism mitigates candidiasis pathology". Journal of Experimetal Medicine. 221 (5) e20231686. doi:10.1084/jem.20231686. PMC 10949073. PMID 38497819.
- ^ "What Is Candida Albicans?". Cleveland Clinic. Archived from the original on 23 July 2025. Retrieved 6 August 2025.
- ^ Kurtzman CP, Rohnett CJ, Ward JM, Brayton C, Gorelick P, Walsh TJ (January 2005). "Multigene Phylogenetic Analysis of Pathogenic Candida Species in the Kazachstania (Arxiozyma) telluris Complex and Description of Their Ascosporic States as Kazachstania bovina sp. nov., K. heterogenica sp. nov., K. pintolopesii sp. nov., and K. slooffiae sp. nov". Journal of Clinical Microbiology. 43 (1): 101–111. doi:10.1128/JCM.43.1.101-111.2005. PMC 540161. PMID 15634957.
- ^ Yamada Y, Malimas T, Vu HT, Yukphan P, Tanasupawat S (March 2024). "The Subdivision of the Genus Kazachstania Zubkova (1971) sensu Kurtzman (2003) (Sacchromycetaceae)". Novelty Journals. 22 (2): 1–10. doi:10.5281/zenodo.10782650.
- ^ "Fungus vs. Fungus: Newly Identified Yeast Might Prevent Life-Threatening Fungal Infections". American Committee for the Weizmann Institute of Science (Press release). Rehovot, Israel. 18 March 2024. Retrieved 6 August 2025.
- ^ Dyer, Rebecca (20 March 2024). "Scientists Discover a New Yeast That Might Stop Invasive Fungal Infections". ScienceAlert. Retrieved 6 August 2025.